Bladder cancer question

Since I have no internet, I would like to ask you if one approach for 1L metastatic UC with low disease burden can be treated with single-agent IO (we expect ORR: 30%, and DoR of 25 months). Chemo-IO have a higher ORR, but they reflect the relatively meaningless chemo-driven response. On patients with high tumor burden, maybe we should treat with chemo as induction, followed by avelumab (or whatever IO agent available).